Concepedia

Inhibition of Poly ADP-Ribose Glycohydrolase Sensitizes Ovarian Cancer Cells to Poly ADP-Ribose Polymerase Inhibitors and Platinum Agents

Emad Matanes, Vanessa M. López‐Ozuna, David Octeau, Tahira Baloch, Florentin Racovitan, Amandeep Kaur Dhillon, Roy Kessous, Oded Raban, Liron Kogan, Shannon Salvador,

Frontiers in Oncology · 2021 · 11 citations · 53 references

DOIFull text

Open access

Abstract

PARG inhibition appears as a complementary strategy to PARP inhibition in the treatment of ovarian cancer, especially in the presence of homologous recombination defects.

References

53

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Lindsey A. Torre, Freddie Bray, Rebecca L. Siegel et al. · CA A Cancer Journal for Clinicians · 2015 · 27.2K citations · Full text

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Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2020 · 21K citations · Full text

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Debra Bell, Andrew Berchuck, Wendy Winckler · Nature · 2011 · 8K citations · Full text

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Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

Ting‐Chao Chou · Cancer Research · 2010 · 5.5K citations

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.1K citations

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