Circulating SERPINA3 Improves Prognostic Stratification in Patients with a <i>De Novo</i> or Worsened Heart Failure

Abstract

In patients with a de novo or worsened HF, increased SERPINA3 levels > 316 μg/mL are associated with increased mortality or unplanned cardiac readmission. Elevated SERPINA3 levels on top of established clinical predictors appear to identify a subgroup of HF patients at higher mortality risk. Prospective studies should further validate its value in prognostic stratification of HF.