Development of Novel Anti-Infective and Antioxidant Azole Hybrids using a Wet and Dry Approach

Abstract

<b>Background:</b> Considering emerging drug resistance in microbes, this work is focused on the synthesis of azole hybrids as novel antimicrobials. <b>Materials & methods:</b> The triazole derivatives were prepared using azide alkyne cycloaddition reaction. The antimicrobial potential of these compounds was evaluated by serial dilution method. <b>Results:</b> A series of azole hybrids containing benzimidazole-1,2,3-triazole skeleton was designed and synthesized via click reaction. Compound <b>4s</b> showed notable antimicrobial activity against <i>Staphylococcus aureus</i> and <i>Candida albicans</i> (MIC 0.0165 μmol/ml), and <b>4q</b> gives remarkable radical scavenging activity (IC₅₀ 0.0092 μmol/ml). The compounds <b>4a, 4k, 4o, 4s, 4x</b>. <b>4m, 4n, 4s, 4t</b> and <b>4x</b> are commendable antibacterial and antifungal molecules, even better than established drugs. Molecular docking reveals that compound <b>4s</b> binds with tyrosyl-tRNA synthetase residues through two H-bonds. <b>Conclusion:</b> Compounds <b>4s</b> and <b>4k</b> may be considered valuable lead compounds for further optimization as antimicrobial drugs.