RSC Advances · 2021 · 31 citations · 61 references
PharmacyPharmaceuticsPharmacologyDrug DeliveryNanoparticle Drug DeliveryTargeted Drug DeliveryCancer Drug DeliveryCancer NanomedicineDrug EncapsulationNanomaterials For Drug DeliveryNanomedicinePh-responsive Drug DeliveryAnticancer Drug LoadingChemotherapy DeliveryDrug Delivery NanocarriersGraphene OxideMetal-organic FrameworksNanocarrier StabilityTargeted DeliveryTargeted Delivery Systems
sustained release characteristics (76% of DOX and 80% of CP) by cleavage of chemical bonding and disruption of the MOFs structure under acidic condition (at pH 5.6). Moreover, DOX@ZIF-8/GO-FA/CP has synergistic cytotoxic effects as compared to the combination of both the drugs without ZIF-8/GO-FA when treating MCF-7 and MDA-MB-231 breast cancer cell lines (with a combination index of 0.29 and 0.75 for MCF-7 and MDA-MB-231 cell-lines, respectively). Hence this system can be applied as an effective platform for smart dual drug delivery in breast cancer treatment through its remarkable manageable multidrug release.
61