Science Immunology · 2021 · 291 citations · 66 references
Life SciencesImmunologyPathobiologyCell SignalingInflammationInnate ImmunityChronic InflammationInflammasome ActivationInflammatory Cell ResponsesInflammatory Cell SignalingInflammatory SignalingNod-like ReceptorsGasdermin D-mediated PyroptosisInflammasome SignalingNlr Family Pyrin Domain-containing 3 InflammasomeNlrp3 Inflammasome
mice. Thus, NLRP3 inflammasome activation overwhelms the protection afforded by GSDMD deficiency, rewiring signaling cascades through mechanisms that include GSDME to propagate inflammation.
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