Structure-based design, synthesis, and evaluation of inhibitors with high selectivity for PARP-1 over PARP-2

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations

Life Sciences, Cancer Biology, Oncology +12

PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

Jean‐Christophe Amé, Véronique Rolli, Valérie Schreiber et al. · Journal of Biological Chemistry · 1999 · 748 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1

Valérie Schreiber, Jean‐Christophe Amé, Pascal Dollé et al. · Journal of Biological Chemistry · 2002 · 705 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

Sherif F. El‐Khamisy · Nucleic Acids Research · 2003 · 656 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2<i>H</i>-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

Keith Menear, Claire Adcock, Robert Boulter et al. · Journal of Medicinal Chemistry · 2008 · 586 citations · Full text

Medicine, Oncology, Pharmacology +16