Hyaluronan heterogeneity in pancreatic ductal adenocarcinoma: Primary tumors compared to sites of metastasis

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

Paolo P. Provenzano, Carlos Cuevas, Amy Chang et al. · Cancer Cell · 2012 · 2.1K citations · Full text

Medicine, Cancer Biology, Oncology +14

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

Michael A. Jacobetz, Derek Chan, Tashinga E. Bapiro et al. · Gut · 2012 · 1.1K citations · Full text

Medicine, Oncology, Pharmacology +17

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

Clifford J. Whatcott, Caroline H. Diep, Ping Jiang et al. · Clinical Cancer Research · 2015 · 635 citations

Medicine, Oncology, Pathology +17

HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma

Sunil R. Hingorani, Lei Zheng, Andrea J. Bullock et al. · Journal of Clinical Oncology · 2017 · 487 citations

Medicine, Oncology, Pharmacology +17

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

Eric Van Cutsem, Margaret A. Tempero, Darren Sigal et al. · Journal of Clinical Oncology · 2020 · 446 citations · Full text

Medicine, Oncology, Pharmacotherapy +14