Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials

Robert C. Doebele, Alexander Drilon, Luis Paz‐Ares, +35

The Lancet Oncology

HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma

Sunil R. Hingorani, Lei Zheng, Andrea J. Bullock, +16

Journal of Clinical Oncology

NanotherapeuticsPathologyPhase Ii StudyTumor BiologyOncology +15

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

Eric Van Cutsem, Margaret A. Tempero, Darren Sigal, +24

Journal of Clinical Oncology

In vivo targeting of B-cell lymphoma with glycan ligands of CD22

Weihsu C. Chen, Gladys C. Completo, Darren Sigal, +3

Blood

Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer

Mitesh J. Borad, Shantan Reddy, Nathan Bahary, +14

Journal of Clinical Oncology

HALO 109-301: A randomized, double-blind, placebo-controlled, phase 3 study of pegvorhyaluronidase alfa (PEGPH20) + nab-paclitaxel/gemcitabine (AG) in patients (pts) with previously untreated hyaluronan (HA)-high metastatic pancreatic ductal adenocarcinoma (mPDA).

Margaret A. Tempero, Eric Van Cutsem, Darren Sigal, +17

Journal of Clinical Oncology

PathologyPharmacotherapyTumor BiologyPancreatic CancerOncology +14

Very long-term eradication of minimal residual disease in patients with hairy cell leukemia after a single course of cladribine

Darren Sigal, Robert W. Sharpe, Carol Burian, +1

Blood

Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing

Arkaitz Ibarra, Jiali Zhuang, Yue Zhao, +14

Nature Communications

Efficacy and safety of entrectinib in patients with NTRK fusion-positive (NTRK-fp) Tumors: Pooled analysis of STARTRK-2, STARTRK-1 and ALKA-372-001

George D. Demetri, Luis Paz‐Ares, Anna F. Farago, +17

Annals of Oncology

Surgical OncologyMedicineCancer ManagementPathologyMolecular Oncology +4

Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance

Yuki Nakanishi, Ángeles Durán, Antoine L’Hermitte, +13

Immunity

Mucosal ImmunologyMedicineImmunologyGastroenterologyPathology +7