Antiviral activities of Cucumis metuliferus fruits alkaloids on Infectious Bursal Disease Virus (IBDV)

Abstract

Objective: The toxicity of the alkaloids isolated from the fruit pulp of Cucumis metuliferus was investigated in chicken fibroblast cells. Materials and Methods: The alkaloids from C. metuliferus fruit pulp were isolated and their effects assayed on infectious bursal disease virus (IBDV) using chicken ebryo fibroblast cells. Results: There was no observed structural change on the chicken fibroblast cells when exposed to concentrations of 0.195 and 100 mg/ml of the alkaloids; and there was observed antiviral activities on IBDV at concentration between 6.125 and 100 mg/ml, while concentrations of the alkaloids between 0.195 to 3.125 mg/ml showed no antiviral activities compared to the control. Conclusion: The alkaloid showed good margin of safety on chicken fibroblast cells, with antiviral activities on infectious bursal disease virus (IBDV).