Concepedia

Dithiolane quartets: thiol-mediated uptake enables cytosolic delivery in deep tissue

Rémi Martinent, Salman Tawffik, Javier López‐Andarias, Dimitri Moreau, Quentin Laurent, Stefan Matile

Chemical Science · 2021 · 40 citations · 62 references

DOIFull text

Open access

Concepts

Abstract

, constitutional isomers. Reviving a classic in peptide chemistry, this templated assembly of β quartets promises to expand streptavidin biotechnology in new directions, while the discovery of general cytosolic delivery in deep tissue as an intrinsic advantage further enhances the significance and usefulness of thiol-mediated uptake.

References

62

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

Yichao Yu, Yin Zhang, Margaret Kenrick et al. · Science Translational Medicine · 2011 · 800 citations

, , +17

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

Choi‐Fong Cho, Justin M. Wolfe, Colin M. Fadzen et al. · Nature Communications · 2017 · 333 citations · Full text

, , +17

Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins

Brian R. McNaughton, James J. Cronican, David B. Thompson et al. · Proceedings of the National Academy of Sciences · 2009 · 263 citations · Full text

, , +16

Sequential Intra‐Intercellular Nanoparticle Delivery System for Deep Tumor Penetration

Caoyun Ju, Ran Mo, Jingwei Xue et al. · Angewandte Chemie International Edition · 2014 · 229 citations · Full text

, , +17

Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes

Antoine Goujon, Adai Colom, Karolína Straková et al. · Journal of the American Chemical Society · 2019 · 228 citations · Full text

, , +17