Concepedia

Accurately Controlled Delivery of Temozolomide by Biocompatible UiO-66-NH2 Through Ultrasound to Enhance the Antitumor Efficacy and Attenuate the Toxicity for Treatment of Malignant Glioma

Zhiping Wan, Chunlin Li, Jinmao Gu, Jun Qian, Junle Zhu, Jiaqi Wang, Yinwen Li, Jiahao Jiang, Huairui Chen, Chun Luo

International Journal of Nanomedicine · 2021 · 33 citations · 38 references

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Abstract

In this work, TMZ@UiO-66-NH<sub>2</sub> nanocomposites with ultrasound mediation could effectively improve the killing effect of malignant glioma and decrease TMZ-induced toxicity in normal tissues, demonstrating great potential for the delivery of TMZ in the clinical treatment of malignant gliomas.

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