Concepedia

Rh(<scp>iii</scp>)-Catalyzed C–H allylation/annulative Markovnikov addition with 5-methylene-1,3-dioxan-2-one: formation of isoquinolinones containing a C3 quaternary centre

Yuanfei Zhang, Xinghua Li, Jintong Bai, Zhaoyu Huang, Minhai Yin, Jiarong Sheng, Ying Song

Organic Chemistry Frontiers · 2021 · 19 citations · 47 references

DOI

Concepts

Abstract

Rh( iii )-Catalyzed C–H allylation/annulative Markovnikov addition reaction was disclosed, offering isoquinolinones containing a C3 quaternary centre. By using this method as the key step, the US28 inverse agonist analogs were synthesized.

References

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