Concepedia

One-Year Follow-Up in a Phase 1/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration

Amir H. Kashani, Jane Lebkowski, Firas M. Rahhal, Robert L. Avery, Hani Salehi-Had, Sanford Chen, Clement K. Chan, Neal Palejwala, April Ingram, Wei Dang,

Translational Vision Science & Technology · 2021 · 82 citations · 17 references

DOIFull text

Open access

Abstract

This work describes the first clinical trial, to our knowledge, of a novel implant for advanced dry AMD.

References

17

A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss

Archives of Ophthalmology · 2001 · 3.2K citations · Full text

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

Michiko Mandai, Akira Watanabe, Yasuo Kurimoto et al. · New England Journal of Medicine · 2017 · 1.5K citations · Full text

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Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

Steven D. Schwartz, Carl D. Regillo, Byron L. Lam et al. · The Lancet · 2014 · 1.3K citations

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Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration

Lyndon da Cruz, Kate Fynes, Odysseas Georgiadis et al. · Nature Biotechnology · 2018 · 695 citations

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Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

Volker Busskamp, Jens Duebel, D. Bálya et al. · Science · 2010 · 637 citations · Full text

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