Weighted Gene Co-Expression Network Analysis Identifies ANGPTL4 as a Key Regulator in Diabetic Cardiomyopathy via FAK/SIRT3/ROS Pathway in Cardiomyocyte

Abstract

We found <i>ANGPTL4</i>, <i>ACOT1</i>, <i>DECR1</i>, <i>HMGCS2</i>, and <i>PDK4</i> were significantly increased in diabetic heart. ANGPTL4 could promote cardiac apoptosis <i>via</i> a FAK/SIRT3/ROS dependent signaling pathway in DbCM.