Analysis of Immune Landscape Reveals Prognostic Significance of Cytotoxic CD4+ T Cells in the Central Region of pMMR CRC

Abstract

We demonstrated that the level of CD4⁺ GzmB⁺ T cells located in the center of tumor could provide great prognostic value for pMMR CRC patients. And the application of neoadjuvant chemotherapy further improves the infiltration of CD4⁺ GzmB⁺ T cells in the central compartment. Further studies into the application of CD4⁺ GzmB⁺ T cells in tumor immunotherapy are needed.