The modulation of salience and central executive networks by acute stress in healthy males: An EEG microstates study

Abstract

EEG microstate analysis involves the examination of topographies of the scalp potential fields to indicate the temporal dynamics of resting-state networks on a millisecond time scale, through which we can investigate the subsecond brain dynamics of stress in individuals. The present study implemented the EEG microstate method to explore the temporal dynamic changes of the large-scale brain networks induced by acute stress. The participants (n = 51) were randomly exposed to a stress condition (n = 25) (induced by Trier Social Stress Test, TSST) or a control condition (n = 26). Two 4-min blocks of resting EEG data were recorded before and after the stress/control test to reflect the stress effect on temporal dynamics of EEG microstates. The results showed that the stress group had larger occurrences and coverage of microstate class C during the post-test session than during the pre-test session. This pattern was reversed in the control group. Further, the microstate class C showed positive correlations with negative affect and perceived stress levels following acute stress. The transition probability between the microstates C and D was larger during the post-test session than during the pre-test session in the stress group, but not different in the control group. In addition, the microstate pairs C and D were positively correlated with negative affect and perceived stress levels. The proportion and sequence of EEG microstates class C and D reflected deviations of salience and executive functions following acute stress. We further proposed that the coordination between salience and executive functions was promoted by acute stress.