Early-Onset Cerebral Amyloid Angiopathy and Alzheimer Disease Related to an APP Locus Triplication - Concepedia

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Early-Onset Cerebral Amyloid Angiopathy and Alzheimer Disease Related to an APP Locus Triplication

DOI Full Paper Access

35

Citations

11

References

2021

Year

Lou Grangeon, Kévin Cassinari, Stéphane Rousseau, Bernard Croisile, Maïté Formaglio, Olivier Moreaud, Jean Boutonnât, Nathalie Le Meur, Manuèle Miné, Thibault Coste,

Neurology Genetics

Abstract

Increased copy number of <i>APP</i> is sufficient to cause AD and CAA, with likely earlier onset in case of triplication compared with duplication.

References

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy Anne Rovelet‐Lecrux, Didier Hannequin, Grégory Raux, Nature Genetics Alzheimer's DiseaseCerebral Amyloid AngiopathyDementiaNeurochemical BiomarkersNeurology	2005	1.2K
APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases Hélène-Marie Lanoiselée, Gaël Nicolas, David Wallon, PLoS Medicine	2017	583
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