Essential role of ALKBH5-mediated RNA demethylation modification in bile acid-induced gastric intestinal metaplasia

Ben Yue, Ran Cui, Ruizhe Zheng, Weilin Jin, Chenlong Song, Tianshang Bao, Ming Wang, Fengrong Yu, Enhao Zhao

Molecular Therapy — Nucleic Acids · 2021 · 31 citations · 39 references

DOIFull text

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Concepts

Abstract

A modification-associated positive feedforward loop between ALKBH5 and NF-κB signaling is involved in generating the IM phenotype of gastric epithelial cells. Targeting the ALKBH5/ZNF333/CYLD/CDX2 axis may be a useful therapeutic strategy for gastric IM in patients with bile regurgitation.

References

39