Concepedia

<i>Akkermansia muciniphila</i> and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis

Zhen-Yang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li, Zhan Zhang

Food & Function · 2021 · 153 citations · 29 references

DOI

Concepts

Abstract

could activate AhR signaling by regulating Trp metabolism, thereby attenuating colonic inflammation.

References

29

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

Clara Depommier, Amandine Everard, Céline Druart et al. · Nature Medicine · 2019 · 2.2K citations · Full text

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Gut microbiome structure and metabolic activity in inflammatory bowel disease

Eric A. Franzosa, Alexandra Sirota‐Madi, Julián Ávila-Pacheco et al. · Nature Microbiology · 2018 · 2K citations · Full text

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CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Bruno Lamas, Mathias L. Richard, Valentin Leducq et al. · Nature Medicine · 2016 · 1.4K citations · Full text

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Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation

Marta Wlodarska, Chengwei Luo, Raivo Kolde et al. · Cell Host & Microbe · 2017 · 862 citations · Full text

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A purified membrane protein from <i>Akkermansia muciniphila</i> or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8 <sup>+</sup> T cells in mice

Lijuan Wang, Lei Tang, Yiming Feng et al. · Gut · 2020 · 629 citations · Full text

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