American Journal of Physiology-Endocrinology and Metabolism · 2021 · 108 citations · 14 references
Veterinary MedicineBiochemistryMolecular MedicineDiabetologyInflammationWound HealingDiabetes Mellitus BiochemistryEndothelial DysfunctionOxidative Stress In InflammationWound Healing PhysiologyWound Healing ResponseWound InflammationDiabetic ComplicationsDiabetic Wound HealingDiabetic Wound PathophysiologyDiabetic Wound RepairIron-dependent Lipid PeroxidationPhosphatidylinositol 3-Kinase-akt PathwayPhosphoinositide 3-Kinase PathwayPi3k-akt Signaling Pathway
Ferroptosis-related characteristic changes were found in diabetic wound models. Inhibition of ferroptosis improved inflammatory infiltration of diabetic wounds. PI3K/AKT signal pathway was rescued by restraining of ferroptosis. Mitigation of ferroptosis in diabetic wound promoted the wound healing.
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012
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