Targeting of fibroblast activation protein in rheumatoid arthritis patients: imaging and <i>ex vivo</i> photodynamic therapy

Abstract

In this study the feasibility of selective FAP-tPDT in synovium of rheumatoid arthritis patients ex vivo is demonstrated. Furthermore, this study provides the first indication that FAP-targeted PET/CT can be used to image arthritic joints, an important step towards application of FAP-tPDT as a targeted locoregional therapy for RA.