Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Improve Ovarian Function and Proliferation of Premature Ovarian Insufficiency by Regulating the Hippo Signaling Pathway - Concepedia

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Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Improve Ovarian Function and Proliferation of Premature Ovarian Insufficiency by Regulating the Hippo Signaling Pathway

DOI Full Paper Access

122

Citations

22

References

2021

Year

Zhongkang Li, Mingle Zhang, Jiahua Zheng, Yanpeng Tian, Huihui Zhang, Yi Tan, Qian Li, Jingkun Zhang, Xianghua Huang

Frontiers in Endocrinology

Abstract

This study suggested that hUCMSC-Exos promoted ovarian functions and proliferation by regulating the Hippo pathway. Therefore, exosomal transplantation could be a promising and efficient clinical therapy for POI in the near future.

References

	Year	Citations
Multilineage Potential of Adult Human Mesenchymal Stem Cells Mark F. Pittenger, Alastair M. Mackay, Stephen C. Beck, Science Adult Stem CellMultilineage PotentialBiomedical EngineeringRegenerative MedicineStem Cells	1999	20.9K
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement Massimo Dominici, Katarina Le Blanc, Ingo Mueller, Cytotherapy Regenerative MedicineCell TherapyMinimal CriteriaInternational SocietyMedicine	2006	17.4K
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Hadi Valadi, Karin M. Ekström, Apostolos Bossios, Nature Cell Biology Novel MechanismSystems BiologyNatural SciencesExosome-mediated TransferExtracellular Microvesicles	2007	12.6K
Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles Jan Lötvall, Andrew F. Hill, Fred H. Hochberg, Journal of Extracellular Vesicles	2014	2.6K
ESHRE Guideline: management of women with premature ovarian insufficiency Human Reproduction	2016	1.5K
Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment Kazuhiro Kawamura, Yuan Cheng, Nao Suzuki, Proceedings of the National Academy of Sciences	2013	878
Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling Johnathon D. Anderson, Henrik J. Johansson, Calvin S. Graham, Stem Cells Nuclear Factor-kappab SignalingExtracellular MicrovesiclesBiomedical EngineeringRegenerative MedicineProteomic Technology	2016	527
Clear up this stem-cell mess Douglas Sipp, Pamela Gehron Robey, Leigh Turner Nature Regenerative MedicineStem-cell MessMedicineAdult Stem CellStem Cell Research	2018	270
Apoptosis in Granulosa cells during follicular atresia: relationship with steroids and insulin-like growth factors Yuan Song YU, Hong Sui, Han Zheng, Cell Research Developmental BiologyCell DivisionCell SignalingFollicular AtresiaApoptosis	2004	176
Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD Boxian Huang, Jiafeng Lu, Chenyue Ding, Stem Cell Research & Therapy	2018	175

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