Concepedia

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Improve Ovarian Function and Proliferation of Premature Ovarian Insufficiency by Regulating the Hippo Signaling Pathway

Zhongkang Li, Mingle Zhang, Jiahua Zheng, Yanpeng Tian, Huihui Zhang, Yi Tan, Qian Li, Jingkun Zhang, Xianghua Huang

Frontiers in Endocrinology · 2021 · 122 citations · 22 references

DOIFull text

Open access

Abstract

This study suggested that hUCMSC-Exos promoted ovarian functions and proliferation by regulating the Hippo pathway. Therefore, exosomal transplantation could be a promising and efficient clinical therapy for POI in the near future.

References

22

Multilineage Potential of Adult Human Mesenchymal Stem Cells

Mark F. Pittenger, Alastair M. Mackay, Stephen C. Beck et al. · Science · 1999 · 20.9K citations

, , +16

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

Massimo Dominici, Katarina Le Blanc, Ingo Mueller et al. · Cytotherapy · 2006 · 17.4K citations

, , +12

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi, Karin M. Ekström, Apostolos Bossios et al. · Nature Cell Biology · 2007 · 12.6K citations

, , +10

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles

Jan Lötvall, Andrew F. Hill, Fred H. Hochberg et al. · Journal of Extracellular Vesicles · 2014 · 2.6K citations · Full text

ESHRE Guideline: management of women with premature ovarian insufficiency

Human Reproduction · 2016 · 1.5K citations · Full text