Anti-depressant effects of ethanol extract from <i>Cannabis sativa</i> (hemp) seed in chlorpromazine-induced <i>Drosophila melanogaster</i> depression model

Abstract

CONTEXT: L. (Cannabaceae) has long been used to treat pain, nausea, and depression. OBJECTIVE: depression model. MATERIALS AND METHODS: The normal group was untreated, and the control group was treated with CPZ (0.1% of media) for 7 days. The experimental groups were treated with a single HE treatment (0.5, 1.0, and 1.5% of media) and a mixture of 0.1% CPZ and HE for 7 days. The locomotor activity, behavioural patterns, depression-related gene expression, and neurotransmitters level of flies were investigated. RESULTS: < 0.001) compared to those in the control group. DISCUSSION AND CONCLUSIONS: model. However, additional research is needed to investigate the role of HE administration in behavioural patterns, reduction of the neurotransmitter, and signalling pathways of depression in a vertebrate model system.