Concepedia

Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition

Tao Yao, Lei Zhang, Ye Fu, Lina Yao, Chengjie Zhou, Guozhong Chen

Molecular and Cellular Biology · 2021 · 47 citations · 22 references

DOIFull text

Open access

Concepts

Abstract

. In conclusion, Sa suppresses FOSL1 transcription by downregulating TCF7, thereby inhibiting MMP9 expression and ultimately reducing the renal inflammation and cell apoptosis induced by sepsis.

References

22

Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice

Qian Ren, Fan Guo, Sibei Tao et al. · Biomedicine & Pharmacotherapy · 2019 · 413 citations · Full text

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Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

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Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway

Chunni Lu, Zi‐Guo Yuan, Xiaoli Zhang et al. · International Immunopharmacology · 2012 · 194 citations · Full text

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Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFκB, TNF-α and caspase-3 expression in wistar rats

Wani Arjumand, Amlesh Seth, Sarwat Sultana · Food and Chemical Toxicology · 2011 · 174 citations

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Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells

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