Concepedia

Publication | Open Access

BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program

DOIFull Paper Access

70

Citations

46

References

2021

Year

Dae‐Hwan Kim, Duanchen Sun, William K. Storck, Katherine Welker Leng, Chelsea Jenkins, Daniel J. Coleman, David A. Sampson, Xiangnan Guan, Anbarasu Kumaraswamy, Eva S. Rodansky,
Clinical Cancer Research

Abstract

E2F1 and BRD4 are critical for activating an AR-repressed, t-NEPC lineage plasticity program. BETi is a promising approach to block this program.

References

YearCitations

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