Penetrance of Breast Cancer Susceptibility Genes From the eMERGE III Network

Abstract

Our study provides population-based penetrance estimates for the understudied genes <i>CHEK2</i>, <i>ATM</i>, and <i>PALB2</i> and highlights the importance of using unselected populations for penetrance studies. It also demonstrates the potential clinical impact of genetic testing to improve health care through early diagnosis and preventative screening.