SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2

Liangyou Rui, Minsheng Yuan, Daniel Frantz, +2

Journal of Biological Chemistry

Molecular RegulationSocs1 MutantsInsulin SignalingInflammationUbiquitin-mediated Degradation +15

A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

Brian E. Lavan, Valeria R. Fantin, Ellen T. Chang, +3

Journal of Biological Chemistry

Molecular BiologyInsulin ReceptorInsulin SignalingIrs FamilyProtein Expression +14

Serine/Threonine Phosphorylation of IRS-1 Triggers Its Degradation

Terry M. Pederson, Deborah Kramer, Cristina M. Rondinone

Diabetes

Molecular BiologyInsulin SignalingReceptor Tyrosine KinaseIrs-1 TriggersMobility Shift +16

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

Ruisheng Song, Wei Peng, Yan Zhang, +15

Nature

Insulin ResistanceMetabolic SyndromeCentral RoleInsulin SignalingBiochemistry +11

Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains

Scott Pluskey, Thomas J. Wandless, Christopher T. Walsh, +1

Journal of Biological Chemistry

The CUL7 E3 Ubiquitin Ligase Targets Insulin Receptor Substrate 1 for Ubiquitin-Dependent Degradation

Xinsong Xu, Antonio Sarikas, Dora Dias‐Santagata, +9

Molecular Cell

Signal TransductionBiochemistryDiabetesMetabolic RegulationUbiquitin-dependent Degradation +5

Expression and function of the insulin receptor substrate proteins in cancer

Katerina Mardilovich, Shannon Pankratz

Cell Communication and Signaling

Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading

Reiko Nakao, Katsuya Hirasaka, Jumpei Goto, +15

Molecular and Cellular Biology

Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: correlation with clinical parameters and disease-free survival.

Rafael L. Rocha, Susan G. Hilsenbeck, James G. Jackson, +4

PubMed

Breast OncologyInsulin-like Growth FactorsInsulin SignalingTumor BiologyOncology +14

Mammary Tumorigenesis and Metastasis Caused by Overexpression of Insulin Receptor Substrate 1 (IRS-1) or IRS-2

Robert K. Dearth, Xiaojiang Cui, Hyun‐Jung Kim, +9

Molecular and Cellular Biology

Tumor BiologyInsulin Receptor SubstratesBreast OncologySignaling PathwayIntrinsic Kinase Activity +13