Primary Progressive Aphasia Associated With <i>GRN</i> Mutations

Abstract

This study shows that the most frequent PPA variant associated with <i>GRN</i> mutations is nonamyloid lvPPA, preceding nfvPPA and mixed forms, and illustrates that the language network may be affected at different levels. <i>GRN</i> testing is indicated for patients with PPA, whether familial or sporadic. This finding is important for upcoming <i>GRN</i> gene-specific therapies.