Novel thiazoline–coumarin hybrid compounds containing sugar moieties: synthesis, biological evaluation and molecular docking study as antiproliferative agents

Abstract

1,3-Thiadiazoline–coumarin hybrid compounds containing <sc>d</sc>-glucose and <sc>d</sc>-galactose moieties have the cytotoxicity against MCF-7, HepG2, HeLa, SK-Mel-2, and LU-1 cells and also EGFR and HER2 kinases. Molecular docking showed key roles in enhancing potency against both enzymes.