RUNX1 regulates SMAD1 by transcriptionally activating the expression of USP9X, regulating the activation of hepatic stellate cells and liver fibrosis

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CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis

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Carbon tetrachloride cirrhosis in relation to liver regeneration

G. R. Cameron, W. A. E. Karunaratne · The Journal of Pathology and Bacteriology · 1936 · 358 citations

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Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

Liwei Wu, Qinghui Zhang, Wenhui Mo et al. · Scientific Reports · 2017 · 271 citations · Full text

Medicine, Pathobiology, Pharmacology +17

Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-β-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit p110δ

Tong Zhou, Maocai Luo, Wei Cai et al. · EBioMedicine · 2018 · 187 citations · Full text

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