Overcoming bacteriophage insensitivity in <i>Staphylococcus aureus</i> using clindamycin and azithromycinat subinhibitory concentrations

Abstract

Subinhibitory concentrations of PSI antibiotics could sensitize phage-resistant S. aureus and MRSA strains to phages in vitro and in vivo. This data supports the potential use of phage-PSI antibiotic combination therapies, in particular for difficult-to-treat infections with phage-resistant S. aureus and MRSA strains.