Dysregulation of the Lysophosphatidylcholine/Autotaxin/Lysophosphatidic Acid Axis in Acute‐on‐Chronic Liver Failure Is Associated With Mortality and Systemic Inflammation by Lysophosphatidic Acid–Dependent Monocyte Activation - Concepedia

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Dysregulation of the Lysophosphatidylcholine/Autotaxin/Lysophosphatidic Acid Axis in Acute‐on‐Chronic Liver Failure Is Associated With Mortality and Systemic Inflammation by Lysophosphatidic Acid–Dependent Monocyte Activation

DOI Full Paper Access

45

Citations

35

References

2021

Year

Francesca M. Trovato, Rabiya Zia, Salvatore Napoli, Kate Wolfer, Xiaohong Huang, Phillip E. Morgan, Hannah Husbyn, Marwa Elgosbi, Manuele Lucangeli, Rosa Miquel,

Abstract

ATX up-regulation in ACLF promotes LPA production from LPC. LPA suppresses MerTK/CD163 expression and increases monocyte proinflammatory cytokine production. This metabolic pathway could be investigated to therapeutically reprogram monocytes in ACLF.

References

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