Blocking glutamate mGlu<sub>5</sub> receptors with the negative allosteric modulator CTEP improves disease course in SOD1<sup>G93A</sup> mouse model of amyotrophic lateral sclerosis - Concepedia

Concepedia

Publication | Open Access

Blocking glutamate mGlu<sub>5</sub> receptors with the negative allosteric modulator CTEP improves disease course in SOD1<sup>G93A</sup> mouse model of amyotrophic lateral sclerosis

DOI Full Paper Access

23

Citations

61

References

2021

Year

Marco Milanese, Tiziana Bonifacino, Carola Torazza, Francesca Provenzano, Mandeep Kumar, Silvia Ravera, Roberta Arianna Zerbo, Giulia Frumento, Matilde Balbi, T. P. Nhung Nguyen,

British Journal of Pharmacology

Abstract

Our results suggest that mGlu<sub>5</sub> receptors are promising targets for the treatment of ALS and highlight mGlu5 receptor NAMs as effective pharmacological tools with translational potential.

References

	Year	Citations

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