Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure - Concepedia

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Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure

DOI Full Paper Access

83

Citations

32

References

2021

Year

Flávio A. Borges-Júnior, Danúbia Silva dos Santos, Acaris Benetti, Juliano Z. Polidoro, Aline Cavalcantti T. Wisnivesky, Renato O. Crajoinas, Ednei Luiz Antônio, Leonardo Jensen, Bruno Caramelli, Gerhard Malnic,

Journal of the American Society of Nephrology

Abstract

Prevention of HF progression by EMPA is associated with reduced PT NHE3 activity, restoration of euvolemia, and preservation of renal mass. Moreover, dysregulation of PT SGLT2 may be involved in the pathophysiology of nondiabetic HF.

References

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