Concepedia

Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets

Tiphaine Belleville‐Rolland, Alexandre Leuci, Alexandre Mansour, Benoît Decouture, Fanny Martin, Sonia Poirault‐Chassac, Margot Rouaud, Hippolyte Guérineau, Blandine Dizier, Dominique Pidard,

Thrombosis and Haemostasis · 2021 · 10 citations · 25 references

DOI

Abstract

Our results are in favour of part of MRP4 present at the platelet surface, including in lipid rafts. Lipid raft integrity is necessary for cAMP signalling regulation, although MRP4 and most players of cAMP homeostasis are essentially located outside rafts.

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, , +16

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