Open Forum Infectious Diseases · 2021 · 23 citations · 11 references
Life SciencesInfectious DiseasesPharmacotherapyInfectious Disease PharmacotherapyMolecular VirologyVirologyAntiviral TherapyEmerging Viral DiseasesViral EpidemiologyViral InfectionsViral PathologyViral PersistenceAcute Viral InfectionRespiratory Viral InfectionsSars-cov-2 Antiviral TherapySars-cov-2 InfectionSevere Acute Respiratory SyndromeViral Decay KineticsViral KineticsViral Respiratory Infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.
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Remdesivir for the Treatment of Covid-19 — Final Report
John H. Beigel, Kay M Tomashek, Lori E. Dodd et al. · New England Journal of Medicine · 2020 · 7.7K citations · Full text
Virological assessment of hospitalized patients with COVID-2019
Roman Wölfel, Victor M. Corman, Wolfgang Guggemos et al. · Nature · 2020 · 7.2K citations · Full text
Detection of SARS-CoV-2 in Different Types of Clinical Specimens
Yanli Xu, Ruqin Gao, Roujian Lu et al. · JAMA · 2020 · 5.3K citations · Full text
Temporal dynamics in viral shedding and transmissibility of COVID-19
Xi He, Eric H. Y. Lau, Peng Wu et al. · Nature Medicine · 2020 · 4.7K citations · Full text
Veterinary Medicine, Infectious Disease Control, Infectious Diseases +17