bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 19 citations · 28 references
Veterinary MedicineImmunologyInfectious DiseasesImmunology Of Infectious DiseasesVaccine ImmunologyVaccinologyCell-mediated ImmunityDna VaccinesImmune Response To VaccinationNucleic Acid VaccinesVaccinationVaccines For Emerging PathogensAdaptive Immune EvasionAntibodiesDeoxyribonucleic Acid (Dna) VaccineSars-cov-2 InfectionT-cell ImmunogenicityVaccine-induced Adaptive ImmunityVaccine-induced T Cell ImmunityVaccine-induced T-cell Responses
Abstract Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested.
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Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
Wilfredo F. García-Beltrán, Evan C. Lam, Kerri St. Denis et al. · Cell · 2021 · 1.5K citations · Full text
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
Zijun Wang, Fabian Schmidt, Yiska Weisblum et al. · Nature · 2021 · 1.5K citations · Full text