Life SciencesImmunologyMolecular BiologyImmunopathologyImmunoregulationMolecular ImmunologyB Cell ActivationB Cell BiologyCell-mediated ImmunityImmune RegulationLymphocyte ActivationT Cell BiologyB And T Lymphocyte Attenuator ModulationB And T Lymphocyte Attenuator RegulationB Cell-mediated ImmunityB-cell Mediated ImmunityB7 Family Immunoregulatory LigandsLoss Of Negative Regulation
B and T lymphocyte attenuator (BTLA), identified as an immune inhibitory receptor recently, plays widespreadroles on T and B cells. Emerging evidence has generated plentiful information on the mechanisms which BTLA mediates negative regulation in immune responses and involves in a variety of physiological and pathological processes. The exploration of the biological mechanisms and regulation of BTLA will open possibilities on novel therapeutic strategies in immune-related diseases.