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T he overall aim of the NHS R&D Health Technology Assessment (HTA) programme is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and work in the NHS. Research is undertaken in those areas where the evidence will lead to the greatest benefits to patients, either through improved patient outcomes or the most efficient use of NHS resources.
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Meta-analysis in clinical trials
Rebecca DerSimonian, Nan M. Laird · Controlled Clinical Trials · 1986 · 39.3K citations
K. H. Nicolaides, G.B. Azar, Dominic Byrne et al. · BMJ · 1992 · 1.1K citations · Full text
Medicine, Genetics, Obstetrics +17
Maternal serum screening for Down's syndrome in early pregnancy.
N J Wald, Howard Cuckle, J. W. Densem et al. · BMJ · 1988 · 974 citations · Full text
RANDOMISED CONTROLLED TRIAL OF GENETIC AMNIOCENTESIS IN 4606 LOW-RISK WOMEN
Ann Tabor, Mette Madsen, Erikb. Obel et al. · The Lancet · 1986 · 873 citations
Medicine, Genetics, Obstetrics +8