BMJ · 1992 · 1.1K citations · 9 references
MedicineGeneticsObstetricsMaternal-fetal MedicineObstetric UltrasoundPrenatal DiagnosisChromosomal AbnormalitiesCongenital AnomaliesCongenital MalformationsFetal AnomaliesFetal Anomaly DetectionFetal ImagingChromosomal Abnormality ScreeningFetal Chromosomal AbnormalitiesFetal KaryotypingFetal Ultrasound ScreeningFirst Trimester UltrasonographyGestation PeriodNuchal Translucency ScreeningPrenatal Karyotyping
To examine the significance of fetal nuchal translucency at 10‑14 weeks gestation in predicting abnormal fetal karyotype. A prospective screening study of 827 fetuses at the Harris Birthright Research Centre, using first‑trimester karyotyping to assess the incidence of chromosomal defects. The study found a 3% overall incidence of chromosomal defects, rising to 35% in fetuses with nuchal translucency ≥3 mm versus 1% in those with thinner membranes, indicating that NT ≥ 3 mm is a useful first‑trimester marker.
OBJECTIVE--To examine the significance of fetal nuchal translucency at 10-14 weeks9 gestation in the prediction of abnormal fetal karyotype. DESIGN--Prospective screening study. SETTING--The Harris Birthright Research Centre for Fetal Medicine, King9s College Hospital, London. SUBJECTS--827 fetuses undergoing first trimester karyotyping by amniocentesis or chorionic villus sampling. MAIN OUTCOME MEASURE--Incidence of chromosomal defects. RESULTS--The incidence of chromosomal defects was 3% (28 of 827 cases). In the 51 (6%) fetuses with nuchal translucency 3-8 mm thick the incidence of chromosomal defects was 35% (18 cases). In contrast, only 10 of the remaining 776 (1%) fetuses were chromosomally abnormal. CONCLUSION--Fetal nuchal translucency > or = 3 mm is a useful first trimester marker for fetal chromosomal abnormalities.
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Moshe Bronshtein, Shraga Rottem, N Yoffe et al. · American Journal of Obstetrics and Gynecology · 1989 · 123 citations
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Medicine, Genetics, Obstetrics +17