BMJ · 1992 · 1K citations · 9 references
To examine the significance of fetal nuchal translucency at 10‑14 weeks gestation in predicting abnormal fetal karyotype. A prospective screening study of 827 fetuses at the Harris Birthright Research Centre, using first‑trimester karyotyping to assess the incidence of chromosomal defects. The study found a 3% overall incidence of chromosomal defects, rising to 35% in fetuses with nuchal translucency ≥3 mm versus 1% in those with thinner membranes, indicating that NT ≥ 3 mm is a useful first‑trimester marker.
OBJECTIVE--To examine the significance of fetal nuchal translucency at 10-14 weeks9 gestation in the prediction of abnormal fetal karyotype. DESIGN--Prospective screening study. SETTING--The Harris Birthright Research Centre for Fetal Medicine, King9s College Hospital, London. SUBJECTS--827 fetuses undergoing first trimester karyotyping by amniocentesis or chorionic villus sampling. MAIN OUTCOME MEASURE--Incidence of chromosomal defects. RESULTS--The incidence of chromosomal defects was 3% (28 of 827 cases). In the 51 (6%) fetuses with nuchal translucency 3-8 mm thick the incidence of chromosomal defects was 35% (18 cases). In contrast, only 10 of the remaining 776 (1%) fetuses were chromosomally abnormal. CONCLUSION--Fetal nuchal translucency > or = 3 mm is a useful first trimester marker for fetal chromosomal abnormalities.
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Moshe Bronshtein, Shraga Rottem, N Yoffe et al. · American Journal of Obstetrics and Gynecology · 1989 · 123 citations
Transvaginal Sonography, Nuchal Cystic Hygroma, Ear Molding +4
Diagnosis and significance of cystic hygroma in the first trimester
Mark Cullen, S. Gabrielli, Jacqueline J. Green et al. · Prenatal Diagnosis · 1990 · 116 citations