Creatine promotes cancer metastasis through activation of Smad2/3

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Life Sciences, Biochemistry, Cellular Metabolism +8

Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens.

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Medicine, Cancer Biology, Oncology +16

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

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Life Sciences, Immunology, Oncology +17

Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis

Pengcheng Bu, Kai‐Yuan Chen, Kun Xiang et al. · Cell Metabolism · 2018 · 362 citations · Full text

Medicine, Cancer Biology, Oncology +16

Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer

Xuxu Sun, Sam C. Wang, Yonglong Wei et al. · Cancer Cell · 2017 · 255 citations

Medicine, Genetics, Oncology +16