Organic Letters · 2021 · 27 citations · 69 references
Natural SciencesChemistryCatalysisOrganic ChemistryOrganic SynthesisBoron ChemistryBorylation ReactionsC - H Bond FunctionalizationFunctional Group ToleranceSelectivityStereoselective C-h FunctionalizationSubstrate ScopeSubstrate Scope Expansion
A palladium-catalyzed alkyl C-H borylation with bromide as a traceless directing group is described, providing a convenient approach to access alkyl boronates bearing a β-all-carbon quaternary stereocenter. The protocol features a broad substrate scope, excellent site selectivity, and good functional group tolerance.
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