Concepedia

VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy

Jennifer Bosco, Zhiwei Zhou, Sofie Gabriëls, Mayank Verma, Nan Liu, Brian K. Miller, Gu Sheng, Dianna Lundberg, Yan Huang, Eilish Brown,

Molecular Therapy — Methods & Clinical Development · 2021 · 19 citations · 43 references

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Abstract

mice inhibited the VEGF:Flt-1 interaction, promoted angiogenesis, and improved muscle function. These studies suggest a potential therapeutic benefit of Flt-1 inhibition for patients with Duchenne muscular dystrophy.

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