Concepedia

FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells

Jingchun Wang, Huakan Zhao, Lu Zheng, Yu Zhou, Lei Wu, Yanquan Xu, Xiao Zhang, Guifang Yan, Halei Sheng, Lu Jiang,

Theranostics · 2021 · 47 citations · 48 references

DOIFull text

Open access

Concepts

Abstract

activating SOCE/NFATc2 pathway; in turn, NFATc2 transcriptionally activates FGF19 expression. Targeting this signaling circuit represents a potential strategy for improving the therapeutic efficacy of HCC.

References

48

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians · 2018 · 87.7K citations · Full text

, , +16

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

Yuxing Liao, Jing Wang, Eric J. Jaehnig et al. · Nucleic Acids Research · 2019 · 3.5K citations · Full text

, , +11

LinkedOmics: analyzing multi-omics data within and across 32 cancer types

Suhas Vasaikar, Péter Straub, Jing Wang et al. · Nucleic Acids Research · 2017 · 2.6K citations · Full text

, , +17

STIM1, an essential and conserved component of store-operated Ca2 <b>+</b> channel function

Jack Roos, Paul J. DiGregorio, Andriy V. Yeromin et al. · The Journal of Cell Biology · 2005 · 1.8K citations · Full text

, , +17

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

Sara A. Beddow, Varman T. Samuel, Paul L. Miller et al. · Science · 2011 · 614 citations

, , +15