Concepedia

Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated <i>PHB2</i>

Xiaohong Xiang, Yunong Fu, Kun Zhao, Runchen Miao, Xing Zhang, Xiaohua Ma, Chang Liu, Nu Zhang, Kai Qu

Theranostics · 2021 · 120 citations · 18 references

DOIFull text

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Concepts

Abstract

Our study established the role of PINT87aa as a novel biomarker and a key regulator of cellular senescence in HCC and identified PINT87aa as a potential therapeutic target for HCC.

References

18

Autophagy maintains stemness by preventing senescence

Laura García‐Prat, Marta Martínez‐Vicente, Eusebio Perdiguero et al. · Nature · 2016 · 1.4K citations

, , +9

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

Maolei Zhang, Kun Zhao, Xiaoping Xu et al. · Nature Communications · 2018 · 823 citations · Full text

, , +17

A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

Maolei Zhang, Nunu Huang, Xuesong Yang et al. · Oncogene · 2018 · 756 citations

, , +12

A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth

Jinzhou Huang, Min Chen, De Chen et al. · Molecular Cell · 2017 · 723 citations · Full text

, , +12

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

Chaojun Yan, Longlong Gong, Li Chen et al. · Autophagy · 2019 · 402 citations · Full text

, , +17