Norwilsonnol A, an immunosuppressive polycyclic polyprenylated acylphloroglucinol with a spiro[5-oxatricyclo[6.4.0.0^3,7]dodecane-6′,1-1′,2′-dioxane] system from <i>Hypericum wilsonii</i>

Abstract

Norwilsonnol A (<bold>1</bold>), a structurally complex polycyclic polyprenylated acylphloroglucinol (PPAP) bearing an unprecedented scaffold, together with a new biosynthetic analogue, norwilsonnol B (<bold>2</bold>), were isolated from <italic>Hypericum wilsonii</italic>.