Concepedia

The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents

Kim Tae-Hun, Mohammad Neaz Morshed, Ashwini M. Londhe, Ji Woong Lim, Ha E Lee, Suengmok Cho, Sung J. Cho, Hayoung Hwang, Sang Min Lim, Jae Yeol Lee,

Journal of Enzyme Inhibition and Medicinal Chemistry · 2021 · 15 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

, which restored the mitochondrial membrane potential, ATP production, and cell viability under Aβ-induced mitochondrial toxicity. These compounds recovered learning and memory function in acute AD model mice with improved pharmacokinetic properties.

References

25

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

Salvatore Oddo, Antonella Caccamo, Jason D. Shepherd et al. · Neuron · 2003 · 4.1K citations · Full text

, , +12

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

Heng Du, Lan Guo, Fang Fang et al. · Nature Medicine · 2008 · 932 citations · Full text

, , +14

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

Jemma Gatliff, Daniel A. East, James Crosby et al. · Autophagy · 2014 · 212 citations · Full text

, , +17

Structure and activity of tryptophan-rich TSPO proteins

Youzhong Guo, Ravi Kalathur, Qun Liu et al. · Science · 2015 · 171 citations

, , +13

Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism

Fei Li, Jian Liu, Yi Zheng et al. · Science · 2015 · 164 citations · Full text

, , +13