Oridonin ameliorates noise-induced hearing loss by blocking NLRP3 - NEK7 mediated inflammasome activation

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Laetitia Agostini, Fabio Martinon, Kimberly Burns et al. · Immunity · 2004 · 1.7K citations · Full text

Inflammation, Muckle-wells Autoinflammatory Disorder, Il-1β-processing Inflammasome +12

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

Yuan He, Melody Yue Zeng, Dahai Yang et al. · Nature · 2016 · 1.2K citations · Full text

Nlrp3 Activation Downstream, Potassium Efflux, Signal Transduction +8

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Hongbin He, Hua Jiang, Yun Chen et al. · Nature Communications · 2018 · 746 citations · Full text

Inflammation, Covalent Nlrp3 Inhibitor, Nlrp3 Inflammasome Assembly +14

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Hexin Shi, Ying Wang, Xiaohong Li et al. · Nature Immunology · 2015 · 711 citations · Full text

Inflammation, Signal Transduction, Signaling Pathway +12

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

Jonathan L. Schmid‐Burgk, Dhruv Chauhan, Tobias Schmidt et al. · Journal of Biological Chemistry · 2015 · 433 citations · Full text