Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes

Staging of brain pathology related to sporadic Parkinson’s disease

Heiko Braak, Kelly Del Tredici, Udo Rüb et al. · Neurobiology of Aging · 2002 · 10.8K citations

Medicine, Neurology, Neuroscience +13

Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

Alexander Zimprich, Saskia Biskup, Petra Leitner et al. · Neuron · 2004 · 3.1K citations · Full text

Life Sciences, Genetics, Neuroscience +14

Genome-wide association study reveals genetic risk underlying Parkinson's disease

Javier Simón‐Sánchez, Claudia Schulte, José Brás et al. · Nature Genetics · 2009 · 2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +10

Culturing hippocampal neurons

Gary Banker · Nature Protocols · 2006 · 1.7K citations

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

Laura A. Volpicelli‐Daley, Kelvin C. Luk, Tapan P. Patel et al. · Neuron · 2011 · 1.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +14