Eurosurveillance · 2021 · 202 citations · 7 references
Veterinary MedicineInfectious Disease ControlInfectious DiseasesEpidemiologyInfectious Disease EpidemiologyRisk AssessmentDisease ControlDisease Risk AssessmentHealth Risk AssessmentMorbidity AnalysisPandemic PreparednessPandemic ResponseCase Fatality Risk AssessmentComorbidity-based Risk ProfilingDisease Severity EstimationHazard Ratio ModelingPandemic MortalityPandemic RiskPandemic Risk AssessmentPandemic Spread Patterns
The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.
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